tlr7 8 Search Results


tlr9 antagonist  (MedChemExpress)
94
MedChemExpress tlr9 antagonist
The hypoxic microenvironment induced NET formation through the TLR4/p38 MAPK pathway in neutrophils. A , The mRNA expression of TLR2, TLR4, <t>TLR9</t> and RAGE in neutrophils treated with hypoxic-CM from GC cells was measured by qRT‒PCR. B , Neutrophils isolated from healthy individuals were pretreated with inhibitors of TLR2, TLR4, TLR9 and RAGE for 1 h prior to coculture with hypoxic-CM from GC cells, and the p-p38 level in neutrophils was measured by western blotting. C , NET formation was detected with MPO and citH3 staining. Magnification: 20 × . Scale bars: 50 μm. All values are the means ± SDs. ns = not significant, ** P < 0.01
Tlr9 Antagonist, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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stemmacstm passaging solution xf  (Miltenyi Biotec)
92
Miltenyi Biotec stemmacstm passaging solution xf
The hypoxic microenvironment induced NET formation through the TLR4/p38 MAPK pathway in neutrophils. A , The mRNA expression of TLR2, TLR4, <t>TLR9</t> and RAGE in neutrophils treated with hypoxic-CM from GC cells was measured by qRT‒PCR. B , Neutrophils isolated from healthy individuals were pretreated with inhibitors of TLR2, TLR4, TLR9 and RAGE for 1 h prior to coculture with hypoxic-CM from GC cells, and the p-p38 level in neutrophils was measured by western blotting. C , NET formation was detected with MPO and citH3 staining. Magnification: 20 × . Scale bars: 50 μm. All values are the means ± SDs. ns = not significant, ** P < 0.01
Stemmacstm Passaging Solution Xf, supplied by Miltenyi Biotec, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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tlr7 8 functions  (MedChemExpress)
94
MedChemExpress tlr7 8 functions
The hypoxic microenvironment induced NET formation through the TLR4/p38 MAPK pathway in neutrophils. A , The mRNA expression of TLR2, TLR4, <t>TLR9</t> and RAGE in neutrophils treated with hypoxic-CM from GC cells was measured by qRT‒PCR. B , Neutrophils isolated from healthy individuals were pretreated with inhibitors of TLR2, TLR4, TLR9 and RAGE for 1 h prior to coculture with hypoxic-CM from GC cells, and the p-p38 level in neutrophils was measured by western blotting. C , NET formation was detected with MPO and citH3 staining. Magnification: 20 × . Scale bars: 50 μm. All values are the means ± SDs. ns = not significant, ** P < 0.01
Tlr7 8 Functions, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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tlr7 8 agonists  (MedChemExpress)
91
MedChemExpress tlr7 8 agonists
The hypoxic microenvironment induced NET formation through the TLR4/p38 MAPK pathway in neutrophils. A , The mRNA expression of TLR2, TLR4, <t>TLR9</t> and RAGE in neutrophils treated with hypoxic-CM from GC cells was measured by qRT‒PCR. B , Neutrophils isolated from healthy individuals were pretreated with inhibitors of TLR2, TLR4, TLR9 and RAGE for 1 h prior to coculture with hypoxic-CM from GC cells, and the p-p38 level in neutrophils was measured by western blotting. C , NET formation was detected with MPO and citH3 staining. Magnification: 20 × . Scale bars: 50 μm. All values are the means ± SDs. ns = not significant, ** P < 0.01
Tlr7 8 Agonists, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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maleimide moiety  (MedChemExpress)
93
MedChemExpress maleimide moiety
The hypoxic microenvironment induced NET formation through the TLR4/p38 MAPK pathway in neutrophils. A , The mRNA expression of TLR2, TLR4, <t>TLR9</t> and RAGE in neutrophils treated with hypoxic-CM from GC cells was measured by qRT‒PCR. B , Neutrophils isolated from healthy individuals were pretreated with inhibitors of TLR2, TLR4, TLR9 and RAGE for 1 h prior to coculture with hypoxic-CM from GC cells, and the p-p38 level in neutrophils was measured by western blotting. C , NET formation was detected with MPO and citH3 staining. Magnification: 20 × . Scale bars: 50 μm. All values are the means ± SDs. ns = not significant, ** P < 0.01
Maleimide Moiety, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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tlr7-associated cytokine ifn-α  (Coley Pharmaceutical)
90
Coley Pharmaceutical tlr7-associated cytokine ifn-α
The hypoxic microenvironment induced NET formation through the TLR4/p38 MAPK pathway in neutrophils. A , The mRNA expression of TLR2, TLR4, <t>TLR9</t> and RAGE in neutrophils treated with hypoxic-CM from GC cells was measured by qRT‒PCR. B , Neutrophils isolated from healthy individuals were pretreated with inhibitors of TLR2, TLR4, TLR9 and RAGE for 1 h prior to coculture with hypoxic-CM from GC cells, and the p-p38 level in neutrophils was measured by western blotting. C , NET formation was detected with MPO and citH3 staining. Magnification: 20 × . Scale bars: 50 μm. All values are the means ± SDs. ns = not significant, ** P < 0.01
Tlr7 Associated Cytokine Ifn α, supplied by Coley Pharmaceutical, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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tlr7 agonist-dsp-0509  (Boston Biomedical)
90
Boston Biomedical tlr7 agonist-dsp-0509
Use of <t> TLR7 </t> agonists as adjuvant in active clinical trials (* www.clinicaltrials.gov ).
Tlr7 Agonist Dsp 0509, supplied by Boston Biomedical, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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smac hydrogel  (SMAC Corp)
90
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Use of <t> TLR7 </t> agonists as adjuvant in active clinical trials (* www.clinicaltrials.gov ).
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tlr7/8 agonist ana975 (isatorabine)  (Novartis)
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Use of <t> TLR7 </t> agonists as adjuvant in active clinical trials (* www.clinicaltrials.gov ).
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novel tlr7/8 dual agonist d018  (Comeau Technique)
90
Comeau Technique novel tlr7/8 dual agonist d018
Use of <t> TLR7 </t> agonists as adjuvant in active clinical trials (* www.clinicaltrials.gov ).
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imidazoquinoline-based tlr-7/8 agonist  (Vaccitech Ltd)
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Vaccitech Ltd imidazoquinoline-based tlr-7/8 agonist
Use of <t> TLR7 </t> agonists as adjuvant in active clinical trials (* www.clinicaltrials.gov ).
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Image Search Results


The hypoxic microenvironment induced NET formation through the TLR4/p38 MAPK pathway in neutrophils. A , The mRNA expression of TLR2, TLR4, TLR9 and RAGE in neutrophils treated with hypoxic-CM from GC cells was measured by qRT‒PCR. B , Neutrophils isolated from healthy individuals were pretreated with inhibitors of TLR2, TLR4, TLR9 and RAGE for 1 h prior to coculture with hypoxic-CM from GC cells, and the p-p38 level in neutrophils was measured by western blotting. C , NET formation was detected with MPO and citH3 staining. Magnification: 20 × . Scale bars: 50 μm. All values are the means ± SDs. ns = not significant, ** P < 0.01

Journal: Cell Communication and Signaling : CCS

Article Title: Neutrophil extracellular traps induced by the hypoxic microenvironment in gastric cancer augment tumour growth

doi: 10.1186/s12964-023-01112-5

Figure Lengend Snippet: The hypoxic microenvironment induced NET formation through the TLR4/p38 MAPK pathway in neutrophils. A , The mRNA expression of TLR2, TLR4, TLR9 and RAGE in neutrophils treated with hypoxic-CM from GC cells was measured by qRT‒PCR. B , Neutrophils isolated from healthy individuals were pretreated with inhibitors of TLR2, TLR4, TLR9 and RAGE for 1 h prior to coculture with hypoxic-CM from GC cells, and the p-p38 level in neutrophils was measured by western blotting. C , NET formation was detected with MPO and citH3 staining. Magnification: 20 × . Scale bars: 50 μm. All values are the means ± SDs. ns = not significant, ** P < 0.01

Article Snippet: The inhibitors used in this study included an HMGB1 antagonist (HY-N0184, MCE, USA), a p38 MAPK pathway inhibitor (HY-12839, MCE, USA), a p65 NF-KB pathway inhibitor (HY-138537, MCE, USA), an ERK pathway inhibitor (HY-112287, MCE, USA), a TLR2 antagonist (HY-112146, MCE, USA), a TLR4 antagonist (HY-107575, MCE, USA), a TLR9 antagonist (HY-131952, MCE, USA), and a RAGE antagonist (HY-P2268).

Techniques: Expressing, Isolation, Western Blot, Staining

Use of TLR7 agonists as adjuvant in active clinical trials (* www.clinicaltrials.gov ).

Journal: Cancer treatment reviews

Article Title: In vivo cancer vaccination: which dendritic cells to target and how?

doi: 10.1016/j.ctrv.2018.10.012

Figure Lengend Snippet: Use of TLR7 agonists as adjuvant in active clinical trials (* www.clinicaltrials.gov ).

Article Snippet: 3 , NCT03416335 A Study of DSP-0509 in Patients With Advanced Solid Tumors to Determine the Safety and the Pharmacokinetic Profile , Neoplasms (44) , • TLR7 agonist-DSP-0509 , • Phase I, single group assignment and open- label. , • Recruiting. • Start date: 1st June 2018 • Completion date: July 2020 , • Boston Biomedical, Inc • Syneos Health.

Techniques: Adjuvant, Clinical Proteomics, Labeling

Use of TLR3 agonists as adjuvant in a selection of active clinical trials (* www.clinicaltrials.gov ).

Journal: Cancer treatment reviews

Article Title: In vivo cancer vaccination: which dendritic cells to target and how?

doi: 10.1016/j.ctrv.2018.10.012

Figure Lengend Snippet: Use of TLR3 agonists as adjuvant in a selection of active clinical trials (* www.clinicaltrials.gov ).

Article Snippet: 3 , NCT03416335 A Study of DSP-0509 in Patients With Advanced Solid Tumors to Determine the Safety and the Pharmacokinetic Profile , Neoplasms (44) , • TLR7 agonist-DSP-0509 , • Phase I, single group assignment and open- label. , • Recruiting. • Start date: 1st June 2018 • Completion date: July 2020 , • Boston Biomedical, Inc • Syneos Health.

Techniques: Adjuvant, Selection, Clinical Proteomics, In Situ, Activity Assay, Immunofluorescence, Recombinant, Immunopeptidomics, Labeling